Bleeding disorders overview

• related: Hemeonc
• tags: #hemeonc

• Intrinsic bleeding disorder
  • prolonged PTT
  • hemophilia A(8)/B: nl PT, bleeding time, plt count
    • replace with DDAVP and aminocaproic acid for hemophilia A
    • can also give factor 8
  • vWF: increased PTT and bleeding time
    • riscocetin test for diagnosis
    • DDAVP and aminocaproic acid
• Extrinsic bleeding disorder
  • prolonged PT/INR
• vitamin K, coumadin: 2, 7, 9, 10, C, S
  • both intrinsic and extrinsic. Factor 7 shortest half life, so PT goes up first

factor 5 leiden

vWF